What Is The Difference Between a Union and Nonunion Fracture?

What Is The Difference Between a Union and Nonunion Fracture?

Katie Wilkinson

By 

Katie Wilkinson

Published 

Dec 17, 2024

Breaking my leg sucked, but waiting seven months for it to heal has been even suckier—I'm in an unlucky percentage of pilon fractures that develop tibial nonunion, which basically means my bone is not healing as it should. In this post, I'll break down what these terms mean and why they're important for your recovery.

In this article:

Understanding bone healing

When you break a bone, your body kicks into repair mode with a process that happens in stages: inflammation, soft callus formation, hard callus development, and finally, remodeling to restore strength and shape. While most bone fractures follow this pattern, pilon fractures are more complicated because they often involve high-impact injuries, multiple fragments, and damage to surrounding tissues, which can slow down or disrupt healing.

Bone healing depends on several factors, starting with the type and severity of the injury—pilon fractures, for example, are much harder to heal than simpler breaks. Proper alignment, surgical fixation with plates or screws, and good blood supply are all critical for recovery. Factors like age, smoking, nutrition, and underlying health conditions can also impact how quickly and completely your bone heals.

What is a union fracture?

A union fracture is what each of us with a broken bone hopes for—it means your bone has healed completely. Healing happens in stages: a clinical union is when you can move the area without pain, while a radiological union is when X-rays show the bone is fully connected.

Signs that you're reaching union include less pain, better mobility, and the gradual return of strength. Your doctor will also look for bone formation on X-rays and check for no visible gaps between the broken pieces of bone.

What is a nonunion fracture?

A nonunion fracture happens when a fracture fails to heal within the expected healing time frame, usually around 6-9 months. There are two main types of nonunion: hypertrophic nonunion, where the bone tries to heal but lacks the stability it needs, and atrophic nonunion, where the bone doesn't produce enough healing material.

Causes of nonunion include poor fixation, lack of blood supply to the area, or even infections. Signs of a nonunion fracture include ongoing pain, swelling, difficulty bearing weight, and X-rays that show gaps in the bone or no signs of progress in healing.

Understanding the differences

Understanding the distinction between these terms is helpful in understanding your recovery and having more informed conversations with your doctor.

Union

  • A union means your bone is healing as expected, with steady progress through the stages of repair (soft callus, hard callus, and remodeling).
  • Signs include reduced pain, better mobility, and diagnostic confirmation through X-rays showing bridging callus and bone consolidation.

Delayed union

  • Delayed union occurs when healing takes longer than usual, but the fracture healing is still progressing.
  • Factors like poor blood supply, inadequate nutrition, or the complexity of the fracture (common with pilon fractures) can contribute to delays.
  • Signs include persistent pain and swelling with some evidence of healing on X-rays, but not at the rate expected for the type of fracture.

Nonunion

  • Nonunion happens when the fracture has completely stopped healing. This means the bone won't heal on its own without medical intervention.
  • Causes can include infection, instability of the fracture site, or insufficient blood supply.
  • Signs include chronic pain, swelling, and X-rays showing no callus formation or significant gaps between bone fragments.

Why this matters for pilon fracture patients

Pilon fractures have a high risk of delayed union or nonunion fractures. Studies suggest that 15-20% of pilon fractures develop nonunion because of the severity of the injury and disruption of blood supply. Delayed union or nonunion can seriously impact your quality of life—additional surgical treatments can be costly, painful, and demoralizing. If you can stay proactive in your recovery, regularly check in with your orthopedic specialist, and intervene if/when healing stalls, you are more likely to achieve better functional outcomes and avoid prolonged disability.

Tips for bone healing and avoiding bone nonunion

Healing your bone and reducing the risk of nonunion calls for good habits:

  • Focus on a diet rich in protein, calcium, and vitamin D to give your body what it needs for bone repair.
  • Quit smoking if you haven't already, as it slows fractured bone healing.
  • Stay physically active, within your surgeon's treatment recommendations, to improve circulation.
  • Follow your surgeon's post-op instructions, whether about weight-bearing restrictions, immobilization, or starting physical therapy.
  • If your doctor recommends it, tools like bone growth stimulators or certain supplements can help healing.

What to do if you develop a nonunion fracture

Nonunion doesn't mean your bone will never heal; it just means that healing has stalled and won't continue without intervention. With the right treatment of nonunions, many nonunion fractures can still heal successfully.

The current gold standard for treatment is autologous cancellous bone grafts, meaning bone grafts taken from your own body. Bone from another part of the body (often, the iliac crest) is taken and transplanted to the nonunion site to act as scaffolding for new bone to grow.

Additional treatments for nonunion fractures include:

  • Stem cell therapy harvested from bone marrow to promote bone regeneration.
  • Growth factor injections such as platelet-derived growth factor, vascular endothelial growth factor, or insulin-like growth factor.
  • Bone graft substitutes, including synthetic materials (e.g., calcium phosphate), demineralized bone matrix, or biologics like Bone Morphogenetic Proteins.
  • Bone stimulation through electrical currents or low-intensity pulsed ultrasound to enhance healing.
  • Custom orthopedic implants or surgical fixators to stabilize the fracture and ensure proper alignment.
  • Hyperbaric oxygen therapy (HBOT) to improve oxygen delivery and blood supply to the nonunion site.
  • Autologous platelet-rich plasma (PRP) therapy delivers growth factors from your own blood to stimulate healing.

While it takes longer and is more frustrating than a typical healing process, advancements in orthopedic care make it possible to restart healing in most cases. Work with your doctor to address the issue early and follow through with your care plan.

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